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CAS RN: 554-92-7 | Product Number: T3525
Trimethobenzamide Hydrochloride
Purity: >98.0%(T)(HPLC)
Synonyms:
- N-[4-[2-(Dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide Hydrochloride
Product Documents:
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Product Number | T3525 |
Purity / Analysis Method | >98.0%(T)(HPLC) |
Molecular Formula / Molecular Weight | C__2__1H__2__8N__2O__5·HCl = 424.92 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Refrigerated (0-10°C) |
Condition to Avoid | Heat Sensitive |
Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
CAS RN | 554-92-7 |
Related CAS RN | 138-56-7 |
Reaxys Registry Number | 3813405 |
PubChem Substance ID | 354334765 |
MDL Number | MFCD00057999 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Melting point | 187.0 to 191.0 °C |
NMR | confirm to structure |
Properties (reference)
Melting Point | 190 °C |
Solubility in water | Soluble |
GHS
Pictogram | |
Signal Word | Warning |
Hazard Statements | H302 : Harmful if swallowed. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
H.S.code* | 2924.29-000 |
Application
Trimethobenzamide Hydrochloride: A Benzamide Derivative Used as an Antiemetic Agent
Trimethobenzamide hydrochloride (Ro 2-9578) is a benzamide derivative which has been used as an antiemetic agent used to prevent nausea and vomiting. Although the mechanism of action remains unknown exactly, it works by blocking one of the chemical messengers that stimulates nausea and vomiting. (The product is for research purpose only.)
References
- Antiemetic activity of 4-(2-dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl)benzylamine hydrochloride (Ro2-9578)
- Trimethobenzamide hydrochloride [N-[p-[2-(dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide monohydrochloride]
- The antiemetic drug trimethobenzamide prevents hypophagia due to acetylsalicylate, but not to 5-HT1B or 5-HT1C agonists
- An Improved Process for Trimethobenzamide Hydrochloride
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