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CAS RN: 129101-54-8 | Product Number: R0093
Rivastigmine L-Tartrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3-[(S)-1-(Dimethylamino)ethyl]phenyl N-Ethyl-N-methylcarbamate L-Tartrate
- N-Ethyl-N-methylcarbamic Acid 3-[(S)-1-(Dimethylamino)ethyl]phenyl Ester L-Tartrate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Quantity |
|---|---|---|---|---|
| 1G |
S$265.50
|
≥40 | 39 |
|
| 5G |
S$888.00
|
25 | 22 |
|
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* The storage conditions are subject to change without notice.
| Product Number | R0093 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__2__2N__2O__2·C__4H__6O__6 = 400.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 129101-54-8 |
| Related CAS RN | 123441-03-2 |
| PubChem Substance ID | 135727179 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 124.0 to 128.0 °C |
| Specific rotation [a]20/D | +4.0 to +7.0 deg(C=5, methanol) |
Properties (reference)
| Melting Point | 126 °C |
| Specific Rotation | 5° (C=5,MeOH) |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
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| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | FA9550000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2924.29-000 |
Application
Rivastigmine Tartrate: A Dual Inhibitor of Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE)
Rivastigmine tartrate is an inhibitor of two cholinesterase enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Rivastigmine activates central cholinergic nervous system by increasing the concentration of acetylcholine (ACh) in brain through reversible inhibition of its hydrolysis by AChE and BuChE. For comparison, another cholinesterase inhibitor, donepezil hydrochloride [D4099] shows high selectivity for AChE over BuChE.. Rivastigmine tartrate is used for the treatment of Alzheimer’s disease. For your reference, [D5326] is a synthetic intermediate of rivastigmine L-tartrate. (The product is for research purpose only.)
References
- Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro
- Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine
- Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors
- A review of rivastigmine: a reversible cholinesterase inhibitor
- A stability indicating LC method for Rivastigmine hydrogen tartrate
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