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CAS RN: 5142-23-4 | Product Number: M2518
3-Methyladenine
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Purity:
Synonyms:
- 6-Amino-3-methylpurine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 200MG |
S$193.50
|
37 | 30 | Contact Us |
|
|
| 1G |
S$657.00
|
2 | 28 | Contact Us |
|
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* The storage conditions are subject to change without notice.
| Product Number | M2518 |
| Molecular Formula / Molecular Weight | C__6H__7N__5 = 149.16 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 5142-23-4 |
| Reaxys Registry Number | 146087 |
| PubChem Substance ID | 253660841 |
| MDL Number | MFCD00010531 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
Properties (reference)
| Melting Point | 300 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | AU6520000 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
3-Methyladenine (3-MA): A PI3K inhibitor - An Autophagy Inhibitor
3-Methyladenine (3-MA) inhibits phosphoinositide 3-kinases (PI3K) such as wortmannin [W0007], and is generally used as an inhibitor of autophagy which is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Recently, in addition to its role in autophagy, 3-MA has been implicated in cancer research. (The product is for research purpose only.)
References
- 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
- 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism
- 3-Methyladenine inhibits autophagy in tobacco culture cells under sucrose starvation conditions
- Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model
- Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase
- Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells
PubMed Literature
Articles/Brochures
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Specifications
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