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CAS RN: 122647-32-9 | Product Number: I0946
Ibutilide Hemifumarate
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Purity: >98.0%(HPLC)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time | Quantity |
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|---|---|---|---|---|---|---|
| 100MG |
S$532.50
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1 | 0 | Contact Us |
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| Product Number | I0946 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__0H__3__6N__2O__3S·^^1/__2C__4H__4O__4 = 442.62 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 122647-32-9 |
| Related CAS RN | 122647-31-8 |
| PubChem Substance ID | 253662069 |
| Merck Index (14) | 4883 |
| MDL Number | MFCD01715410 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Maximum Absorption Wavelength | 267(EtOH) nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | PB0475700 |
Transport Information:
| H.S.code* | 2935.90-000 |
Application
Ibutilide Fumarate: The First "Pure" Class III Antiarrhythmic Agent
Ibutilide fumarate, the first "pure" class III antiarrhythmic agent, is shown to increase the refractory period and action potential duration of myocardial cells. At a cellular level, ibutilide fumarate exerts two main actions: dihydropyridine Ca2+ channel blockers and potent inhibition of the delayed rectifier K+ current (IKr), by binding within the channel pore cavity upon channel gating. (The product is for research purpose only.)
References
- Ibutilide, a new compound with potent class III antiarrhythmic activity, activates a slow inward sodium current in guinea pig ventricular cells
- Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells: concentration-, time-, voltage-, and use-dependent effects
- Ibutilide (a review)
- Structural determinants of HERG channel block by clofilium and ibutilide
- Cardioversion of persistent atrial fibrillation by a combination of atrial specific and non-specific class III drugs in the goat
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