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CAS RN: 302962-49-8 | Product Number: D5949
Dasatinib
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Purity: >95.0%(T)(HPLC)
Synonyms:
- N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]thiazole-5-carboxamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Quantity |
|---|---|---|---|---|
| 1G |
S$147.00
|
≥60 | 12 |
|
| 5G |
S$508.50
|
2 | 9 |
|
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* The storage conditions are subject to change without notice.
| Product Number | D5949 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__6ClN__7O__2S = 488.01 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 302962-49-8 |
| Reaxys Registry Number | 9966762 |
| PubChem Substance ID | 468591660 |
| MDL Number | MFCD11046566 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 280 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | XJ3466000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2934.10-000 |
Application
Dasatinib: A Multitargeted Inhibitor of Tyrosine Kinases
Dasatinib (BMS-354825) is an oral, multitargeted inhibitor of tyrosine kinases, including BCR-ABL fusion protein, SRC family kinases (SRC, LCK, YES, FYN), c-KIT, erythropoietin-producing hepatocellular receptor A2 (EPHA2), and platelet-derived growth factor receptor β (PDGFRβ). In vitro studies have shown that dasatinib is active in leukemic cell lines representing variants of imatinib mesylate [I0936] sensitive and resistant disease. Dasatinib inhibits the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines overexpressing BCR-ABL. (The product is for research purpose only.)
References
- Discovery of N-(2-Chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent AntitumorActivity in Preclinical Assays
- Dasatinib (BMS-354825) Pharmacokinetics and Pharmacodynamic Biomarkers in Animal Models Predict Optimal Clinical Exposure
- Dasatinib: an anti-tumor agent via Src inhibition (a review)
- Method development and validation for the quantification of dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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