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CAS RN: 179324-69-7 | Product Number: B5741
Bortezomib
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Purity: >98.0%(HPLC)
Synonyms:
- (R)-3-Methyl-1-[(S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido]butylboronic Acid
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 10MG |
S$117.00
|
≥40 | 0 | Contact Us |
|
|
| 50MG |
S$409.50
|
6 | 0 | It can be shipped in about 2 weeks after ordering |
|
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* The storage conditions are subject to change without notice.
| Product Number | B5741 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__5BN__4O__4 = 384.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 179324-69-7 |
| Reaxys Registry Number | 8723817 |
| PubChem Substance ID | 468590677 |
| Merck Index (14) | 1351 |
| MDL Number | MFCD09056737 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -50.0 to -55.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 123 °C |
| Solubility in water | Soluble |
| Degree of solubility in water | 76 mg/l |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | ED7771666 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2933.99-000 |
Application
Adeno-associated virus vector transduction enhancer
Bortezomib increases transduction by adeno-associated virus (AAV) vectors.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
Application
Bortezomib: A Reversible Inhibitor of the 26S Proteasome in Mammalian Cells
Bortezomib (PS-341) is a reversible inhibitor of the 26S proteasome in mammalian cells. The proteasome is an abundant multi-enzyme complex that provides the main pathway for degradation of intracellular proteins in eukaryotic cells. The 26S proteasome is a large protein complex that degrades ubiquitinated proteins. The ubiquitin-proteasome pathway plays an essential role in regulating the intracellular concentration of specific proteins. The orderly degradation of cellular proteins is critical for normal cell cycling and function, and inhibition of the ubiquitin-proteasome pathway with bortezomib results in cell-cycle arrest and apoptosis. (The product is for research purpose only.)
References
- The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
- The proteasome: a suitable antineoplastic target (a review)
- Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives (a review)
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