Published TCIMAIL newest issue No.197
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CAS RN: 857447-79-1 | Product Number: B5440
Bis(tetrabutylammonium) Dihydrogen Pyrophosphate
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Purity: >96.0%(T)
Synonyms:
- Bis(tetrabutylammonium) Dihydrogen Diphosphate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€166.00
|
1 | Contact Us |
|
| 1G |
€527.00
|
3 | Contact Us |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B5440 |
| Purity / Analysis Method | >96.0%(T) |
| Molecular Formula / Molecular Weight | C__3__2H__7__4N__2O__7P__2 = 660.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 857447-79-1 |
| Reaxys Registry Number | 9031313 |
| PubChem Substance ID | 354334284 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 96.0 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2923900090 |
Application
Solid-phase Synthesis of DNA and RNA 5'-O-Triphosphates
After oligonucleotide synthesis:
5-Chloro-saligenyl-N,N-diisopropylphosphoramidite (Reagent I, C3326) is coupled to the 5'-end of the DMT-off oligonucleotide. Oxidation of the formed 5'-phosphite using the same oxidizing reagent used in standard oligonucleotide synthesis leads to support-bonded 5'-cycloSal-oligonucleotides. Reaction with pyrophosphate (Reagent II, B5440) yields the corresponding 5'-triphosphates. The 5'-triphosphorylated oligonucleotides are obtained after cleavage from the support in high purity and excellent yields. The whole reaction sequence was adapted to be used on a standard oligonucleotide synthesizer.
5-Chloro-saligenyl-N,N-diisopropylphosphoramidite (Reagent I, C3326) is coupled to the 5'-end of the DMT-off oligonucleotide. Oxidation of the formed 5'-phosphite using the same oxidizing reagent used in standard oligonucleotide synthesis leads to support-bonded 5'-cycloSal-oligonucleotides. Reaction with pyrophosphate (Reagent II, B5440) yields the corresponding 5'-triphosphates. The 5'-triphosphorylated oligonucleotides are obtained after cleavage from the support in high purity and excellent yields. The whole reaction sequence was adapted to be used on a standard oligonucleotide synthesizer.
References
- Solid-Phase Synthesis of DNA and RNA 5’-O-Triphosphates Using cycloSal Chemistry
PubMed Literature
Articles/Brochures
TCIMAIL
[TCIMAIL No.183] New Reagents for the Synthesis of Triphosphates[Product Highlights] Phosphorous Compounds for the Synthesis of Triphosphonates of Oligonucleotides
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