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CAS RN: 10347-81-6 | Product Number: M2527
Maprotiline Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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| 1G |
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| Product Number | M2527 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__3N·HCl = 313.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 10347-81-6 |
| Related CAS RN | 10262-69-8 |
| Reaxys Registry Number | 5463242 |
| PubChem Substance ID | 253661753 |
| Merck Index (14) | 5748 |
| MDL Number | MFCD00079464 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 240.0 to 244.0 °C |
Properties (reference)
| Melting Point | 242 °C |
| Solubility (soluble in) | Methanol |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | KJ4555000 |
Transport Information:
| H.S.code* | 2921.49-000 |
Application
Maprotiline: An Inhibitor of Norepinephrine Uptake
Maprotiline, a tetracyclic second-generation antidepressant, exhibits strong inhibitory effects on norepinephrine uptake but interferes relatively little on serotonin and dopamine reuptake. Maprotiline is metabolized by polymorphic CYP2D6 and CYP2Cl9 isoforms in the liver. (The product is for research purpose only.)
References
- Maprotiline: a review of its pharmacological properties and therapeutic efficacy in mental depressive states
- Chemistry, Pharmacology, Pharmacokinetics, Adverse Effects, and Efficacy of the Antidepressant Maprotiline Hydrochloride (a review)
- Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine
- Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine
- Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats
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