Disulfiram (other name: tetraethylthiuram disulfide), developed in the 19th century,1) has been used as an organic accelerator of rubber vulcanization.2,3) There are some applications using dislfiram for an additive of living radical polymerization,4,5) a Ca2+-ATPase activator,6) a V-ATPase inhibitor7) and so on.
It was revealed by E. Jacobsen et al. in 1948 that dislfiram absorbed into the body inhibits aldehyde dehydrogenase during the ethanol metabolism, and provokes acute symptoms because of the accumulation of acetaldehyde in the body.8) So disfiram has a deterrent effect of alcoholism.9)
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Aldehyde Dehydrogenase Inhibitor for Anti-Alcoholism Research
References
- 1)Über Elektrolytische Darstellung eines eeuen Dithiondisulfids sowie über diejenige von Dithiondisulfiden
- 2)Preventing the bacterial oxidation of rubber
- 3)Studies on the Reaction between Thiocarbamylsulfenamides and Diebenzothiazyl Disulfide
- 4)Role of initiator-transfer agent-terminator (iniferter) in radical polymerizations: Polymer design by organic disulfides as iniferters
- 5)The in situ atom transfer radical polymerization of MMA using the TD-FeCl3-PPh3 initiating system
- 6)Stimulation of the Ca2+-ATPase of sarcoplasmic reticulum by disulfiram
- 7)Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry
- 8)A drug sensitizing the organism to ethyl alcohol
- 9)Pharmacological treatment of alcohol dependence: Target symptoms and target mechanisms
