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CAS RN: 155270-99-8 | Product Number: I1100
Istradefylline
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
$87.00
|
35 | 7 | Contact Us | |
| 1G |
$259.00
|
≥40 | 0 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | I1100 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__4N__4O__4 = 384.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 155270-99-8 |
| Reaxys Registry Number | 7863436 |
| PubChem Substance ID | 468592093 |
| MDL Number | MFCD00928421 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 191.0 to 195.0 °C |
Properties (reference)
| Melting Point | 193 °C |
| Maximum Absorption Wavelength | 362(CH2Cl2) nm |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | UO8414732 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Istradefylline: A Selective Adenosine A2A Receptor Antagonist
Istradefylline (KW-6002) is a selective adenosine A2A receptor antagonist. Adenosine A2A receptors are a G protein-coupled receptor (GPCR), and also one of the receptors of adenosine. In the brain, adenosine A2A receptors are considered to be present specifically in the basal ganglia, and are thought to be involved in the regulation of motor functions. The degeneration or abnormality observed in Parkinson's disease (PD) is believed to occur in the basal ganglia. Istradefylline as a high affinity and selectivity for A2A receptors. Reportedly, istradefylline has improved motor function in patients with advanced PD including loss of L-DOPA [D0600] efficacy. (The product is for research purpose only.)
References
- Adenosine A2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys
- Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP
- Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson’s disease (a review)
- Istradefylline: First Global Approval (a review)
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