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CAS RN: 285983-48-4 | Product Number: D6115
Doramapimod
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Purity: >98.0%(T)(HPLC)
Synonyms:
- BIRB 796
- 1-[3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholinoethoxy)naphthalen-1-yl]urea
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 50MG |
$255.00
|
≥40 | 0 | Contact Us |
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| Product Number | D6115 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__3__1H__3__7N__5O__3 = 527.67 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 285983-48-4 |
| Reaxys Registry Number | 9170597 |
| MDL Number | MFCD09752957 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 114.0 to 118.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 116 °C |
GHS
Related Laws:
| RTECS# | YT0099000 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Doramapimod: A Highly Potent Inhibitor of p38 MAPK
The p38 mitogen-activated protein kinase (p38 MAPK) is a Ser/Thr kinase, originally isolated from lipopolysaccharide-stimulated monocytes. It plays a crucial role in regulating the production of pro-inflammatory cytokines, such as tumor necrosis factor (TNF) and interleukin-1.1) Therefore, blocking this kinase may offer an effective therapy for the treatment of many inflammatory diseases. Doramapimod (BIRB-796) is a highly potent inhibitor of p38 MAPK that blocks TNFα release in LPS-stimulated THP-1 cells.2) Furthermore, doramapimod is also used in regenerative medicine area. Doramapimod enhances the stem cell activity of cultured umbilical cord blood-derived hematopoietic cells cultured in serum-free medium supplemented with SCF, TPO, and FLT3L.3) Doramapimod also blocks the osteogenic differentiation effect of myocilin on human mesenchymal stem cells (HMSCs).4) (The product is for research purpose only.)
References
- 1) p38 MAP kinase inhibitors: Many are made, but few are chosen (a review)
- 2) BIRB796 Inhibits All p38 MAPK Isoforms in Vitro and in Vivo
- 3) RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion
- 4) Myocilin Stimulates Osteogenic Differentiation of Mesenchymal Stem Cells through Mitogen-activated Protein Kinase Signaling
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