Maximum quantity allowed is 999
Please select the quantity
CAS RN: 190728-25-7 | Product Number: D5070
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
×
![]()
×
![4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline")
Purity:
Synonyms:
- 4-(4-Aminophenoxy)-6,7-dimethoxyquinoline
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
$29.00
|
5 | 3 | It can be shipped in about 2 weeks after ordering | |
| 1G |
$112.00
|
2 | 12 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | D5070 |
| Molecular Formula / Molecular Weight | C__1__7H__1__6N__2O__3 = 296.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 190728-25-7 |
| Reaxys Registry Number | 1490304 |
| PubChem Substance ID | 354334606 |
| MDL Number | MFCD19685633 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 211.0 to 215.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 214 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2933.49-000 |
Application
A Synthetic Intermediate of VEGFR-2 Tyrosine Kinase Inhibitors and PDGFR Tyrosine Kinase Inhibitors
This reagent has been used for the synthesis of vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitors such as cabozantinib [CAS: 849217-68-1],1-3) and platelet-derived growth factor receptor (PDGFR) tyrosine kinase inhibitors.4,5)
References
- 1)Novel Potent Orally Active Selective VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Structure-Activity Relationships, and Antitumor Activities of N-Phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas
- 2)N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors
- 3)Degradation kinetics study of cabozantinib by a novel stability-indicating LC method and identification of its major degradation products by LC/TOF-MS and LC-MS/MS
- 4)Synthesis and structure-activity relationship for new series of 4-phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase
- 5)Identification of Potent and Selective Inhibitors of PDGF Receptor Autophosphorylation
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.