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CAS RN: 199875-69-9 | Product Number: A3446
N-Arachidonoyl Dopamine
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Purity: >98.0%(HPLC)
Synonyms:
- NADA
- (5Z,8Z,11Z,14Z)-N -[2-(3,4-Dihydroxyphenyl)ethyl]-5,8,11,14-eicosatetraenamide
- (5Z,8Z,11Z,14Z)-N-(3,4-Dihydroxyphenethyl)icosa-5,8,11,14-tetraenamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
$133.00
|
15 | 15 | Contact Us |
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| Product Number | A3446 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__4__1NO__3 = 439.64 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 199875-69-9 |
| Reaxys Registry Number | 7779367 |
| MDL Number | MFCD03412031 |
Specifications
| Appearance | Colorless to Yellow clear liquid |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Flash point | 341 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2924.19-000 |
Application
N-Arachidonoyldopamine: An Endogenous Cannabinoid
N-Arachidonoyldopamine (NADA) is was first synthesized as a pharmacological tool to study the endogenous cannabinoid system (ECS).1) Later NADA and other N-acyldopamines were identified as endogenous cannabinoids in the mammalian nervous tissue.2,3) It has been reported that NADA acts as an agonist of the cannabinoid 1 (CB1) receptors.1-3) It is selective for CB1 over CB2 receptors. Furthermore, NADA also acts as an agonist of the transient receptor potential vanilloid type 1 (TRPV1) ion channel, also known as the capsaicin receptor.2,3) For your reference, the endogenous cannabinoid system (ECS) modulates neuronal and immune cell function, both of which play key roles in pain, therapeutics targeting this system hold promise as novel analgesics.3) (The product is for research purpose only.)
References
- 1) N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo
- 2) An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
- 3) N-arachidonoyl dopamine: a novel endocannabinoid and endovanilloid with widespread physiological and pharmacological activities (a review)
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