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CAS RN: 23680-84-4 | Product Number: A2151
4-Amino-2-chloro-6,7-dimethoxyquinazoline
Purity: >98.0%(HPLC)(N)
Synonyms:
- 2-Chloro-6,7-dimethoxy-4-quinazolinamine
Product Documents:
Size | Unit Price | Same Day | 2-3 Business Days |
---|---|---|---|
5G |
$25.00
|
4 | Contact Us |
25G |
$79.00
|
1 | 4 |
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Product Number | A2151 |
Purity / Analysis Method | >98.0%(HPLC)(N) |
Molecular Formula / Molecular Weight | C__1__0H__1__0ClN__3O__2 = 239.66 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
CAS RN | 23680-84-4 |
Reaxys Registry Number | 747463 |
PubChem Substance ID | 87560582 |
MDL Number | MFCD00051734 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(with Total Nitrogen) | min. 98.0 % |
Properties (reference)
Melting Point | 302 °C(dec.) |
GHS
Pictogram | |
Signal Word | Warning |
Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
H.S.code* | 2933.99-000 |
Application
A Synthetic Intermediate of α1-Adrenoceptor Antagonists
This product is used as a synthetic intermediate of α1-adrenoceptor antagonists such as doxazosin mesylate [D4126]1-3) and terazosin hydrochloride [T2751]4).
References
- 1) 2,4-Diamino-6,7-dimethoxyquinazolines. 1. 2-[4-(1,4-Benzodioxan-2-ylcarbonyl)piperazin-1-yl] derivatives as α1-adrenoceptor antagonists and antihypertensive agents
- S. F. Campbell, M. J. Davey, J. D. Hardstone, B. N. Lewis, M. J. Palmer, J. Med. Chem. 1987, 30, 49.
- 2) Practical chemical and enzymatic technologies for (S)-1,4-benzodioxan-2-carboxypiperizine intermediate in the synthesis of (S)-doxazosin mesylate
- 3) A reliable multigram synthesis of (±) doxazosin
- 4) 4-amino-2[4-[1-(benzyloxycarbonyl)-2(S)-[[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6,7-dimethoxyquinazoline (L-765,314): A potent and selective α1b adrenergic receptor antagonist
PubMed Literature
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