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CAS RN: 172889-27-9 | Product Number: P2833
PP 2
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Purity: >97.0%(T)(HPLC)
Synonyms:
- 1-(tert-Butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
$146.00
|
≥40 | 0 | Contact Us | |
| 50MG |
$509.00
|
10 | 15 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | P2833 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__6ClN__5 = 301.78 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 172889-27-9 |
| Reaxys Registry Number | 9409964 |
| PubChem Substance ID | 468592746 |
| MDL Number | MFCD01568210 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 210.0 to 214.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 212 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | UR0717045 |
Transport Information:
| H.S.code* | 2933.59-000 |
Application
PP2: A Potent SRC-Tyrosine Kinase Inhibitor
SRC kinase family is a family of non-receptor tyrosine kinases (Non-RTKs) that acts as a key mediator of cell signaling pathway pathways, and regulate cell adhesion, growth, and differentiation. PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the SRC family of protein tyrosine kinases.1) Therefore, PP2 has been widely used as a reagent for cancer research.2, 3) (The product is for research purpose only.)
References
- 1) Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
- 2) Kinase inhibitors and cytotoxic drug resistance (a review)
- 3) Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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