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CAS RN: 524955-09-7 | Product Number: C3150
3-Chloro-4-(2-pyridylmethoxy)aniline
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Purity: >98.0%(GC)(T)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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|---|---|---|---|---|---|
| 1G |
$29.00
|
4 | 0 | Contact Us | |
| 5G |
$94.00
|
2 | 0 | Contact Us |
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| Product Number | C3150 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__2H__1__1ClN__2O = 234.68 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 524955-09-7 |
| Reaxys Registry Number | 9908340 |
| PubChem Substance ID | 354333976 |
| MDL Number | MFCD08699389 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 91.0 to 95.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 93 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2933.39-000 |
Application
A Synthetic Intermediate of Neratinib (NKI-272)
This product is used for the synthesis of neratinib (NKI-272) which is a dual tyrosine kinase inhibitor of the human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases, used as an anticancer agent
References
- Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity
- Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives
- Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides
PubMed Literature
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