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CAS RN: 4360-12-7 | Product Number: A3236
Ajmaline
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Purity: >97.0%(T)(HPLC)
Synonyms:
- (17R,21α)-Ajmalan-17,21-diol
- Cardiorythmine
- (5aR,6S,8R,9S,11aS,12aR,13R)-9-Ethyl-5-methyl-5a,6,8,9,10,11,11a,12-octahydro-5H-6,10:11,12a-dimethanoindolo[3,2-b]quinolizine-8,13-diol
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 1G |
$219.00
|
12 | 2 |
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* The storage conditions are subject to change without notice.
| Product Number | A3236 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__6N__2O__2 = 326.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 4360-12-7 |
| Reaxys Registry Number | 94358 |
| PubChem Substance ID | 468590186 |
| MDL Number | MFCD00135652 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Specific rotation | +138 to +146 deg (C=1,CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 160 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | AX8050000 |
Transport Information:
| H.S.code* | 2939.79-000 |
Application
Ajmaline: An Indole Alkaloid with Ion Channel Inhibitory Activity
Ajmaline is an indole alkaloid that was first isolated from the root of Rauvolfia serpentina, a species of flower in the milkweed family Apocynaceae.1) Ion channels alter the ion balance of cardiac cells, by adjusting the amount of electrical charge to them. Therefore if the electrical properties of a cell are faulty this can result in a disturbance of the heart rhythm (arrhythmia). Ajmaline has ion (such as potassium and potassium) channel inhibitory and anti-arrhythmic activities, and has been widely used as a class Ia anti-arrhythmic agent.2-4) (The product is for research purpose only.)
References
- 1) Quantitative Determination of Reserpine, Ajmaline, and Ajmalicine in Rauvolfia serpentina by Reversed-Phase High-Performance Liquid Chromatography
- 2) Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action
- 3) Effect of ajmaline on transient outward current in rat ventricular myocytes
- 4) Inhibition of cardiac Kv1.5 and Kv4.3 potassium channels by the class Ia anti-arrhythmic ajmaline: mode of action
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