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Highly Reactive Electrophilic Trifluoromethylating Reagent: Umemoto Reagent IV
The trifluoromethyl group is a strong electron-withdrawing group and it exhibits unique properties such as high electron negativity and hydrophobicity. As a result, efficient trifluoromethylating reagents are valuable in the research fields of bioactive compounds, agrochemicals and materials.1) Umemoto reagent IV is a new trifluoromethylating reagent developed by Umemoto et al.2) Umemoto reagent IV is activated by trifluoromethoxy groups, strong electron-withdrawing groups, so that it has higher reactivity than a conventional series of Umemoto reagents. The trifluoromethylation of electron-deficient methylenes and nitrogen-containing aromatic rings proceeds with Umemoto reagent IV to give the corresponding target compounds according to the equations below.
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References
- 1) Introduction of Fluorine and Fluorine-Containing Functional Groups
- 2) Synthesis and applications of S-(trifluoromethyl)-2,8-bis(trifluoromethoxy)dibenzothiophenium triflate (Umemoto reagent IV)
