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9-(2,2-Dicyanovinyl)julolidine for Cellular Imaging and the Detection of Protein Aggregation
9-(2,2-Dicyanovinyl)julolidine (1) is a fluorescent molecular rotor, whose fluorescence properties are greatly affected by the angle of rotation of the olefin group extending off of its lone aromatic ring. Since 1 is sensitive to changes in the viscosity of its local environment, it is utilized in a wide range of applications such as food processing, polymer chemistry, and cellular imaging. In recent years, there have even been reports of its application in biochemical research, for example in the detection of the aggregation of polysorbate-containing IgG formulations1) as well as that of lipid phase transition in bacteria.2)
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References
- 1) Fluorescent Molecular Rotors as Dyes to Characterize Polysorbate-Containing IgG Formulations
- 2) Fluorescent Probe DCVJ Shows High Sensitivity for Characterization of Amyloid β-Peptide Early in the Lag Phase
