Maximum quantity allowed is 999
Please select the quantity
CAS RN: 128625-52-5 | Product Number: R0296
Reagents for Condensation Reactions (1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate) (HPMC encapsulated)
×
![]()
×
Purity:
Synonyms:
- 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate ca. 0.25 mmol/capsule (HPMC encapsulated)
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10EACH |
$55.00
|
16 | 0 | Contact Us |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
Supplemental Product Information:
Contents (per one capsule)
- 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate : ca. 0.25 mmol
Directions for Use
- Each capsule contains all reagents for a single use on 0.25 mmol scale condensation reaction (amide coupling reaction) between carboxylic acid and amine.
Typical condition: 0.25 mmol of carboxylic acid and 1.25 equiv. of amines and 2.0 equiv. of base in DMF (0.25 M) at 30 °C.
Related Products
- B1774 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate
| Product Number | R0296 |
| Molecular Formula / Molecular Weight | C__1__8H__2__8F__6N__6OP__2 = 520.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 128625-52-5 |
Specifications
| Appearance | White to Almost white capsule |
| Functionality test (conversion ratio) | min. 95.0 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H317 : May cause an allergic skin reaction. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P273 : Avoid release to the environment. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P391 : Collect spillage. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| H.S.code* | 3822.19-000 |
Application
TCI Practical Example: The Condensation Reaction Using a Capsule Reagent
-
Used Chemicals
-
Procedure
-
Reagents for condensation capsule (1H-benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate) (one capsule) was added to a solution of 4-bromobenzoic acid (40 mg, 0.20 mmol, 1.0 eq.) and morpholine (17 μL, 0.20 mmol, 1.25 eq.) in DMF (1 mL) at room temperature and the mixture was stirred for 2 hours. The reaction solution was diluted with ethyl acetate (5 mL) and filtered through Celite. The organic layer was washed with 1 mol/L HCl aq. (5 mL), sat. NaHCO3 aq. (5 mL) and brine (20 mL), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (hexane: ethyl acetate = 1:1 - 1:2) to afford (4-bromophenyl)(morpholino)methanone (65 mg, 97% yield) as a white solid.
-
Experimenter’s Comments
-
The reaction mixture was monitored by UPLC.
The shape of the capsule is like below image and each capsule includes 1H-benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate (ca. 0.25 mmol).
The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose).
-
Analytical Data
-
(4-Bromophenyl)(morpholino)methanone
1H NMR (400 MHz, CDCl3); δ 7.57 (d, J = 8.4 Hz, 2H), 7.30 (d, J = 8.4 Hz, 2H), 3.74-3.44 (m, 8H).
-
Lead Reference
-
- Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water
-
Other Reference
-
- HPMC: A Biomass-Based Semisynthetic Sustainable Additive Enabling Clean and Fast Chemistry in Water
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.
Other Documents
Related Products
![1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate [Coupling Reagent for Peptide]](/medias/B1774.jpg?context=bWFzdGVyfHJvb3R8MzY5OTd8aW1hZ2UvanBlZ3xhREl5TDJobVppODRPVEk0TnpRNU5EZzJNVEV3TDBJeE56YzBMbXB3Wnd8ZmRkNTNjMzMxNTc1YjRkZWE5MjMyYzkxODg4MWM0MWQ0ZGNhNzlmMzcxODM1ODY2ZjBmOTM4MmI2ZjhjOGIyMQ "1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate [Coupling Reagent for Peptide]")
1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate [Coupling Reagent for Peptide]
| Product # | B1774 |
| CAS RN | 128625-52-5 |
| Purity / Analysis Method: | >98.0%(HPLC) |