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CAS RN: 130-95-0 | Product Number: Q0028
Quinine
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Purity: >98.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
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|---|---|---|---|---|---|
| 25G |
$120.00
|
13 | ≥40 | It can be shipped in about 2 weeks after ordering | |
| 100G |
$332.00
|
4 | 18 | It can be shipped in about 2 weeks after ordering |
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| Product Number | Q0028 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__2__0H__2__4N__2O__2 = 324.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic |
| CAS RN | 130-95-0 |
| Reaxys Registry Number | 5293630 |
| PubChem Substance ID | 87575561 |
| SDBS (AIST Spectral DB) | 2170 |
| Merck Index (14) | 8061 |
| MDL Number | MFCD00198096 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 174.0 to 179.0 °C |
| Specific rotation [a]20/D | -160 to -170 deg(C=2, EtOH) |
| Solubility in Methanol | very faint turbidity |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 177 °C |
| Specific Rotation | -165° (C=2,EtOH) |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | VA6020000 |
Transport Information:
| H.S.code* | 2939.20-000 |
Application
Quinine, an Antimalarial Substance
Quinine is one of the alkaloids which is included in the bark of cinchona tree and has been researched since 19th century.1) It has an anti-malarial activity2-4) and is considered to inhibit heme polymerase of plasmodium and to indicate toxicity to plasmodium. There are other antimalarial substances such as chloroquine diphosphate [C2301], hydroxychloroquine sulfate [H1306] and artemisinin [A2118]. (The product is for research purpose only)
References
- 1)Fatal Dose of Sulphate of Quinine
- 2)Antimalarial Drug Toxicity (a review)
- 3)Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications (a review)
- 4)Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria (a review)
Application
Asymmetric Tandem Michael Addition/Oxidation of Pyrazolones with p-Benzoquinone Using Cinchona Alkaloid Catalysts
Typical Procedure:
p-Benzoquinone (42.6 mg, 0.4 mmol) and quinine (1.3 mg, 2 mol%) are dissolved in 1,2-dichloroethane (2 mL). The solution is stirred at 25 °C for 10 min, after which a 4-substituted pyrazol-5-one (0.2 mmol) is added to the mixture. The solution is stirred at 25 °C for 24 h. Next, the solvent is removed under reduced pressure. The residue is directly subjected to column chromatography (petroleum ether/EtOAc = 10:1–6:1) to afford the desired product.
p-Benzoquinone (42.6 mg, 0.4 mmol) and quinine (1.3 mg, 2 mol%) are dissolved in 1,2-dichloroethane (2 mL). The solution is stirred at 25 °C for 10 min, after which a 4-substituted pyrazol-5-one (0.2 mmol) is added to the mixture. The solution is stirred at 25 °C for 24 h. Next, the solvent is removed under reduced pressure. The residue is directly subjected to column chromatography (petroleum ether/EtOAc = 10:1–6:1) to afford the desired product.
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