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CAS RN: 53-19-0 | Product Number: M3304

Mitotane


Purity: >98.0%(GC)
Synonyms:
  • 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane
  • 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
  • o,p'-DDD
Product Documents:
1G
$68.00
1   0   Contact Us
5G
$244.00
7   1   Contact Us

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* The storage conditions are subject to change without notice.


Product Number M3304
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__1__4H__1__0Cl__4 = 320.03 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image)
CAS RN 53-19-0
Reaxys Registry Number 2056007
PubChem Substance ID 468592398
Merck Index (14) 6216
MDL Number

MFCD00000850

Specifications
Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Melting point 76.0 to 80.0 °C
Solubility in Methanol almost transparency
NMR confirm to structure
Properties (reference)
Melting Point 78 °C
Solubility in water Insoluble
Degree of solubility in water 0.1 mg/l   25 °C
Solubility (soluble in) Ethanol, Methanol
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H370 : Causes damage to organs.
H372 : Causes damage to organs through prolonged or repeated exposure.
H351 : Suspected of causing cancer.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P405 : Store locked up.
Related Laws:
RTECS# KH7880000
Transport Information:
H.S.code* 2903.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Mitotane: An Adrenal-Specific Cytotoxic Agent with Steroid Synthesis Inhibition

Mitotane (o,p'-DDD) is an adrenal-specific cytotoxic agent with an unknown biochemical mechanism of action.1) Scientific reports suggest that mitotane modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.2-4) Therefore, mitotane is used for the treatment of adrenocortical carcinoma (ACC) and Cushing's disease. Recently, mitotane (as an adjuvant) plus etoposide [E0675], doxorubicin [D4193] (HCl salt), and cisplatin [D3371] (called EDP-M) is the established first-line therapy for ACC.5) (The product is for research purpose only.)

References


Product Documents (Note: Some products will not have analytical charts available.)
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