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CAS RN: 36330-85-5 | Product Number: B2491
Fenbufen
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-([1,1'-Biphenyl]-4-yl)-4-oxobutanoic Acid
- 4-(4-Biphenyl)-4-oxobutyric Acid
- γ-Oxo-(1,1'-biphenyl)-4-butanoic Acid
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 5G |
$46.00
|
21 | 4 |
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* The storage conditions are subject to change without notice.
| Product Number | B2491 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__4O__3 = 254.29 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 36330-85-5 |
| Reaxys Registry Number | 2378560 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 185.0 to 189.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 187 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2918.30-000 |
Application
Fenbufen: A Non-Steroidal and Non-Selective Cyclooxygenase (COX) Inhibitor
Fenbufen is a non-steroidal and non-selective cyclooxygenase (COX) inhibitor with anti-inflammatory properties. Fenbufen is a prodrug and its major metabolite, 4-biphenylacetic acid [B1278], is a potent inhibitor of prostaglandin synthesis. The mechanism of action is mainly through inhibition of the enzyme COX in the arachidonic acid pathway, resulting in reduced prostaglandin synthesis. (The product is for research purpose only.)
Reference
- Pharmacologic properties of fenbufen
- Fenbufen: a review of its pharmacological properties and therapeutic use in rheumatic diseases and acute pain
- A review of selected investigational nonsteroidal antiinflammatory drugs of the 1980s
- Microextraction by packed sorbent and high performance liquid chromatography determination of seven non-steroidal anti-inflammatory drugs in human plasma and urine
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