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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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A Novel Electrophilic-Type Trifluoromethylthiolation Reagent, Shibata Reagent II
Shibata et al. have reported a novel trifluoromethylthiolating reaction using an electrophilic-type trifluoromethylthiolation reagent, benzoyl(phenyliodonio)(trifluoromethanesulfonyl)methanide (Shibata Reagent II). This reagent is electrophilic and reacts well with various nucleophiles to afford the CF3S-substituted products. The reaction process is assumed that a reactive trifluoromethylthio (CF3S−) species is generated from the trifluoromethanesulfonyl group by carbene-mediated in situ reduction catalyzed by a copper (I) salt in the presence of an amine. Trifluoromethylthiolated compounds have attracted special interest in the pharmaceutical and agrochemical industries.
