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CAS RN: 74124-79-1 | 제품번호: D1662
Di(N-succinimidyl) Carbonate
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| 포장단위 | 가격 | 당일출고 | 2-3일 이내 출고 |
|---|---|---|---|
| 5G |
₩131,400
|
7 | ≥60 |
| 25G |
₩397,800
|
13 | 문의 |
•본 제품의 재고는 일본 본사의 재고입니다. 주문시, 5일안에 실험실까지 도착됩니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.(SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.(SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
규격표
| Appearance | White to Light gray to Light yellow powder to crystal |
| Purity(Butylamine Method) | min. 98.0 % |
물성치(참고치)
| mp | 215 °C(dec.) |
| Solubility in water | Insoluble |
GHS
| 픽토그램 |
|
| 신호 워드 | Warning |
| 위험물 및 유해 등록 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 주의 사항 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
법규 정보
운송 정보
| HS 번호* | 2925.19-000 |
Application
TCI Practical Example: Condensation Using Di(N-succinimidyl) Carbonate
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Used Chemicals
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Procedure
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To a solution of compound 3-(3,4-dimethoxyphenyl)propionic acid (0.10 g, 0.48 mmol), di(N-succinimidyl) carbonate (0.19 g, 0.62 mmol) in dichloromethane (5.0 mL) was added triethylamine (0.086 mL, 0.62 mmol) at ambient temperature and stirred at same temperature for 30 minutes. The mixture was added 4-methylbenzylamine (0.078 mL, 0.62 mmol) and stirred at same temperature for 1 hour. After completion of the reaction, the solvent was removed under reduced pressure and the residue was purified by column chromatography (ethyl acetate:hexane = 3:7 - 1:1 on silica gel) to give 1 (0.13 g，y. 86%) as a white solid.
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Experimenter’s Comments
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The reaction mixture was monitored by UPLC.
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Analytical Data
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compound 1
1H NMR (400 MHz, CDCl3); δ 7.10 (2H, d, J = 8.0 Hz), 7.05 (2H, d, J = 8.0 Hz), 6.78-6.70 (3H, m), 5.58 (1H, brs), 4.36 (2H, d, J = 5.6 Hz), 3.85 (3H, s), 3.83 (3H, s), 2.94 (2H, t, J = 7.6 Hz), 2.48 (2H, t, J = 7.6 Hz), 2.32 (3H, s).
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Lead Reference
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- A novel active ester synthesis reagent (N,N’-disuccinimidyl carbonate)
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Other References
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- Studies on Lactams IX. A Convenient Synthesis of Lactam Rings
- Synthesis and Reactivity Comparisons of 1-Methyl-3-Substituted Cyclopropene Mini-tags for Tetrazine Bioorthogonal Reactions
Application
A Condensing Reagent
Experimental procedure3): 1 (10 mg, 0.08 mmol) is dissolved in CH2Cl2 and, to this solution, Et3N (10 mg, 0.1 mmol) and N,N’-disuccinimidyl carbonate (26 mg, 0.1 mmol) are added. The resulting solution is stirred for 30 min after which ethanolamine (6 mg, 0.1 mmol) is added. The reaction is stirred at room temperature for an additional 1 hour. The organic solvent is evaporated and the residue is purified by preparative TLC (EtOAc) to afford 11 mg of compound 2 as a colorless oil, in 81% yield.
References
- 1)A novel active ester synthesis reagent (N,N’-disuccinimidyl carbonate)
- 2)Studies on Lactams IX. A Convenient Synthesis of Lactam Rings
- 3)Synthesis and Reactivity Comparisons of 1-Methyl-3-Substituted Cyclopropene Mini-tags for Tetrazine Bioorthogonal Reactions
PubMed Literature
기사 / 브로셔
제품문서 (분석 차트를 제공하지 못할 수도 있으니 양해 바랍니다.)
SDS
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규격표
시험성적서， 각종 증명서
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