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A Versatile and Safe Trifluoromethylthiolating Agent
N-Methyl-N-(trifluoromethylthio)aniline (1) is an electrophilic trifluoromethylthiolating agent and can be used for the reaction with various substances. For example, 1 smoothly reacts with Grignard reagents to afford the corresponding trifluoromethylthiolated products.1) In the reaction with terminal alkynes, the trifluoromethylthiolating reaction proceeds using catalytic amounts of base.2) Furthermore, 1 can be applied to the trifluoromethylthiolation of indoles in the presence of a Brønsted or Lewis acid.3, 4) 1 is a safe and liquid trifluoromethylthiolating agent that it is used for the synthesis of trifluoromethylthiolated compounds attracting attention in the pharmaceutical and agrochemical fields.
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References
- 1)Electrophilic Trifluoromethanesulfanylation of Organometallic Species with Trifluoromethanesulfanamides
- 2)Base-Catalyzed Electrophilic Trifluoromethylthiolation of Terminal Alkynes
- 3)Electrophilic Trifluoromethanesulfanylation of Indole Derivatives
- 4)First and Second Generation of Trifluoromethanesulfenamide Reagent: A Trifluoromethylthiolating Comparison
