Propolis (bee glue) is a mixture of tree resins and dyes collected from plants by honey bees, and their own secretion. Honey bees use it as a building material of the beehive, while humans have used its antibacterial and antitumor activities from B. C. E.
Caffeic acid phenethyl ester (CAPE) is a constituent of propolis, which has various bioactivities. It has been reported that CAPE inhibits NF-κB activation and has antineoplastic, antioxidant, anti-inflammatory, and cytostatic properties.
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A Constituent of Propolis with Various Bioactivities
References
- Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB
- Antioxidant Activities of Caffeic Acid and Its Related Hydroxycinnamic Acid Compounds
- Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation
- Novel and therapeutic effect of caffeic acid and caffeic acid phenethyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism
- Caffeic acid phenethyl ester induces apoptosis by inhibition of NFκB and activation of fas in human breast cancer MCF-7 cells
- The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy-induced and radiotherapy-induced toxicity (a review)
