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CAS RN: 139264-17-8 | Product Number: Z0024
Zolmitriptan
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (S)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
₩116,600
|
1 | 0 | It can be shipped in about 2 weeks after ordering | |
| 1G |
₩405,200
|
29 | 15 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | Z0024 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__1N__3O__2 = 287.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 139264-17-8 |
| Reaxys Registry Number | 7415010 |
| PubChem Substance ID | 253659590 |
| Merck Index (14) | 10189 |
| MDL Number | MFCD00871503 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 136.0 to 140.0 °C |
| Specific rotation [a]20/D | -3.0 to -5.0 deg(C=1、MeOH) |
Properties (reference)
| Melting Point | 138 °C |
| Specific Rotation | -4° (C=1,MeOH) |
| Maximum Absorption Wavelength | 225 nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | RQ2707000 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Zolmitriptan: A Selective 5-HT1B/1D Receptor Agonist
Zolmitriptan is a selective 5-HT1B/1D receptor agonist, belongs to triptans. Zolmitriptan binds with high affinity to 5-HT1 receptor subtypes (5-HT1B, 5-HT1D), and moderate affinity for a serotonergic receptor subtype (5-HT1A). Zolmitriptan is mainly metabolized by CYP1A2 to an initial metabolite N-desmethylzolmitriptan which also has high affinity for 5-HT1B/1D and moderate affinity for 5-HT1A receptors. Animal studies shows that zolmitriptan presumably exerts its therapeutic effects in the treatment of migraine headache through agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system. (The product is for research purpose only.)
References
- Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine?
- Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan)
- Zolmitriptan - a 5-HT1B/D agonist, alcohol, and aggression in mice
- Characterization of 5-HT receptors in human coronary arteries by molecular and pharmacological techniques
- Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan
- Simultaneous measurement of zolmitriptan and its major metabolites N-desmethylzolmitriptan and zolmitriptan N-oxide in human plasma by high-performance liquid chromatography with coulometric detection
- High-performance liquid chromatographic analysis of zolmitriptan in human plasma using fluorescence detection
- A validated chiral LC method for the determination of Zolmitriptan and its potential impurities
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