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CAS RN: 118292-40-3 | Product Number: T3108
Tazarotene
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Purity: >98.0%(GC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
₩105,500
|
8 | 0 | It can be shipped in about 3-4 weeks after ordering | |
| 100MG |
₩688,200
|
31 | 1 | It can be shipped in about 3-4 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | T3108 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__1NO__2S = 351.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 118292-40-3 |
| Reaxys Registry Number | 8159145 |
| PubChem Substance ID | 253662270 |
| Merck Index (14) | 9081 |
| MDL Number | MFCD00867628 |
Specifications
| Appearance | White to Yellow to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 102.0 to 106.0 °C |
Properties (reference)
| Melting Point | 105 °C |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
| RTECS# | US5675100 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Tazarotene: A Synthetic Retinoic Acid Receptor (RAR)-β and γ Selective Retinoid
Retinoids exert their biological effects through two families of nuclear receptors, retinoic acid receptors (RARs) and retinoid X receptors (RXRs). RAR is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans-retinoic acid [R0064] and 9-cis retinoic acid. There are three retinoic acid receptors (RAR-α, β, and γ). Tazarotene is a synthetic RAR-β and γ selective retinoid. Many studies have shown that tazarotene can affect cell proliferation and differentiation through upregulating the expression of tazarotene-induced genes TIG1, TIG2 and TIG3. Tazarotene is used for the treatment of plaque psoriasis and acne vulgaris. (The product is for research purpose only.)
References
- Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin
- Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin
- Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene
- Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis (a review)
- Tazarotene-induced gene 3 is suppressed in basal cell carcinomas and reversed in vivo by tazarotene application
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