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CAS RN: 70-00-8 | Product Number: T2511
Trifluorothymidine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- α,α,α-Trifluorothymidine
- Trifluridine
- 2'-Deoxy-5-trifluoromethyluridine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 100MG |
₩229,400
|
8 | ≥100 |
| 1G |
₩1,533,700
|
14 | 8 |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | T2511 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__1F__3N__2O__5 = 296.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 70-00-8 |
| Reaxys Registry Number | 568095 |
| PubChem Substance ID | 87560183 |
| Merck Index (14) | 9687 |
| MDL Number | MFCD00006534 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +47.0 to +53.0 deg(C=1, H2O) |
Properties (reference)
| Melting Point | 189 °C |
| Specific Rotation | 50° (C=1,H2O) |
| Solubility in water | Soluble |
GHS
Related Laws:
| RTECS# | XP2087500 |
Transport Information:
| H.S.code* | 2940.00-000 |
Application
CRISPR Genome Editing / Research on regenerative medicine
Reference
- Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
Application
Trifluridine: A Fluorinated Pyrimidine Nucleoside with Anti-Herpesvirus and Antitumor Activities
Trifluridine (trifluorothymidine, TFT), a fluorinated pyrimidine nucleoside, is an anti-herpesvirus agent and an antitumor antimetabolite agent. Thymidylate kinase (TK) is a key enzyme in the synthesis of thymidine-5'-monophosphate [T0845, di-Na salt], an essential precursor for DNA biosynthesis. Trifluridine is incorporated into (virus or tumor) DNA as its triphosphate via phosphorylation by thymidylate kinase (TK), ultimately suppressing DNA replication and inhibiting cell proliferation.1-4) Trifluridine has activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and vaccinia virus.1-3) Recently, a combined antitumor agent TAS-102 (trifluridine with tipiracil, a thymidine phosphorylase inhibitor) has been used in clinical. Inclusion of tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. 4-6) (The product is for research purpose only.)
References
- 1) Fluorinated pyrimidines. XXXVII. Effects of 5-trifluoromethyl-2'-deoxyuridine on the synthesis of deoxyribonucleic acid of mammalian cells in culture
- 2) Trifluorothymidine (a review)
- 3) Trifluridine: a review of its antiviral activity and therapeutic use in the topical treatment of viral eye infections
- 4) Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes
- 5) A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA
- 6) TAS-102, a novel antitumor agent: a review of the mechanism of action
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