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CAS RN: 13292-46-1 | Product Number: R0079
Rifampicin
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Purity: >98.0%(T)
Synonyms:
- Rifampin
- Rifamycin AMP
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
₩133,200
|
9 | ≥100 | It can be shipped in about 2 weeks after ordering | |
| 25G |
₩401,500
|
26 | ≥80 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | R0079 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__4__3H__5__8N__4O__1__2 = 822.95 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 13292-46-1 |
| Reaxys Registry Number | 5723476 |
| PubChem Substance ID | 87560354 |
| Merck Index (14) | 8216 |
| MDL Number | MFCD00151389 |
Specifications
| Appearance | Orange to Amber to Dark red powder to crystal |
| Purity(HPLC) | min. 94.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 188 °C(dec.) |
| Solubility (soluble in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | VJ7000000 |
Transport Information:
| H.S.code* | 2941.90-000 |
Application
Rifampicin: A Rifamycin Antibiotic with Activity against a Wide Variety of Organisms including Tuberculosis Germs
Rifampicin (other name: rifampin) is a semisynthetic rifamycin antibiotic, which is chemically synthesized from rifamycin, which is isolated from a strain of the actinomycete Amycolatopsis mediterranei. Rifampicin has activity against a wide variety of organisms, including tuberculosis germs and Staphylococcus aureus, as well as in vitro activity against penicillin-resistant Streptococcus pneumoniae, and many Gram-negative bacteria. Rifampicin inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase, which is responsible for DNA transcription. In contrast, the corresponding mammalian enzymes are not affected by rifampicin. Bacterial resistance to rifampicin is caused by mutations leading to a change in the structure of the β subunit of RNA polymerase. Rifampicin acts as a cytochrome P450 3A4 (CYP3A4) inducer, which increase the activity of CYP3A4. Thus, rifampicin can cause drug interaction with other medications.
References
- Rifampin: A Semisynthetic derivative of rifamycin. Prototype for the future (a review)
- Rifampin, a useful drug for nonmycobacterial infections (a review)
- Rifampin: mechanisms of action and resistance
- Pharmacokinetic interactions with rifampicin: Clinical relevance
- Rifampin and rifabutin drug interactions. An update
PubMed Literature
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