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CAS RN: 63208-82-2 | Product Number: P2751
Pifithrin-α
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
₩275,700
|
34 | ≥60 | Contact Us | |
| 50MG |
₩989,800
|
6 | 30 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | P2751 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__8N__2OS·HBr = 367.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Moisture Sensitive,Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 63208-82-2 |
| Reaxys Registry Number | 4943838 |
| PubChem Substance ID | 468592707 |
| Merck Index (14) | 7421 |
| MDL Number | MFCD00417851 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 192 °C |
GHS
Related Laws:
| RTECS# | KM5784250 |
Transport Information:
| H.S.code* | 2934.20-000 |
Application
Mitophagy research
References
- Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes
- Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart
Application
Pifithrin-α (PFT-α): A p53 Inhibitor
p53 (Also known as Trp53 in mice, TP53 in humans) is a tumor suppressor protein that is frequently inactivated in tumors.1) Pifithrin-α (PFT-α) is a p53 inhibitor that blocks p53-dependent transcriptional activation and apoptosis.2-4) Other p53 Inhibitors: Cyclic Pifithrin-α Hydrobromide [C2826] and Pifithrin-μ [P2048].
References
- 1) Assessing TP53 status in human tumours to evaluate clinical outcome
- 2) A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
- 3) Suppression of p53: a new approach to overcome side effects of antitumor therapy (a review)
- 4) Prospective therapeutic applications of p53 inhibitors (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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