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CAS RN: 20069-09-4 | Product Number: P2361
Piperlongumine
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Purity: >97.0%(HPLC)
Synonyms:
- 5,6-Dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-trans-2-propenyl]-2(1H)-pyridinone
- (E)-1-[3-(3,4,5-Trimethoxyphenyl)acryloyl]-5,6-dihydropyridin-2(1H)-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
₩135,100
|
24 | 10 | It can be shipped in about 3-4 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | P2361 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__9NO__5 = 317.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 20069-09-4 |
| Reaxys Registry Number | 1503970 |
| PubChem Substance ID | 354333528 |
| MDL Number | MFCD00075706 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Melting point | 123.0 to 127.0 °C |
Properties (reference)
| Melting Point | 125 °C |
GHS
Related Laws:
| RTECS# | UU7785850 |
Transport Information:
| H.S.code* | 2933.79-000 |
Application
Piperlongumine: A Pyridone Alkaloid with Anti-Tumor Properties
Piperlongumine is a pyridone alkaloid isolated from Piper longum L. found in southern India and Southeast Asia. Recent reports have shown that piperlongumine have anti-tumor properties. Piperlongumine increases the level of reactive oxygen species (ROS) selectively in tumor cells, and induces apoptotic cell death in tumor cells but not normal cells.
References
- Selective killing of cancer cells by a small molecule targeting the stress response to ROS
- Piperlongumine induces autophagy by targeting p38 signaling
- Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells
- Overview of the therapeutic potential of piplartine (piperlongumine) (a review)
- Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death
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