Maximum quantity allowed is 999
Please select the quantity
CAS RN: 459789-99-2 | Product Number: O0641
Obeticholic Acid
×
![]()
×
Purity: >97.0%(GC)(T)
Synonyms:
- 6-ECDCA
- 6-Ethylchenodeoxycholic Acid
- 6-Ethyl-3α,7α-dihydroxycholan-24-oic Acid
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 1G |
₩294,200
|
Contact Us | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | O0641 |
| Purity / Analysis Method | >97.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__2__6H__4__4O__4 = 420.63 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 459789-99-2 |
| Reaxys Registry Number | 9238543 |
| MDL Number | MFCD16621104 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 97.0 % |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 106.0 to 110.0 °C |
| Specific rotation | +3.3 to +5.5 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 109 °C |
GHS
Related Laws:
| RTECS# | FZ2267000 |
Transport Information:
| H.S.code* | 2918.19-000 |
Application
Obeticholic Acid: A Potent and Selective Agonist of Farnesoid X Receptor (FXR)
Farnesoid X receptor (FXR), a nuclear receptor, is a ligand-activated transcription factor involved in the control of bile acid (BA) synthesis and enterohepatic circulation, and a regulator of glucose and lipid metabolism. Obeticholic acid (6-ECDCA, INT-747) is a semi-synthetic mimetic of the primary human bile acid, chenodeoxycholic acid (CDCA) [C0750]. There are reports that obeticholic acid is a potent and selective activator of FXR that reduces hepatic steatosis and fibrosis in animal models of fatty liver disease. (The product is for research purpose only.)
References
- 6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity
- Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action (a review)
- The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.