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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 152520-56-4 | Product Number: N0954
Nebivolol Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 20MG |
₩66,600
|
9 | 6 | It can be shipped in about 3-4 weeks after ordering | |
| 100MG |
₩227,600
|
12 | 0 | It can be shipped in about 3-4 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | N0954 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__5F__2NO__4·HCl = 441.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 20MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 152520-56-4 |
| Related CAS RN | 118457-14-0 |
| PubChem Substance ID | 253661900 |
| Merck Index (14) | 6432 |
| MDL Number | MFCD07357273 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 223.0 to 228.0 °C |
Properties (reference)
| Melting Point | 226 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| H.S.code* | 2932.99-000 |
Application
β1-アドレナリン受容体選択的アンタゴニスト作用と一酸化窒素 (NO) の遊離を介する薬理作用を併せ持つ化合物，ネビボロール塩酸塩
Nebivolol hydrochloride is a third-generation β-adrenergic receptor antagonist (β-blocker). It differs from other β-adrenergic receptor antagonists (propranolol hydrochloride [P0995], carvedilol [C2260], bisoprolol hemifumarate [B3994] and atenolol [A1414]) as it combines highly selective β1-adrenergic receptor antagonist properties with nitric oxide-mediated vasodilatory actions and beneficial effects on endothelial function. (The product is for research purpose only.)
References
- Pharmacological and hemodynamic profile of nebivolol, a chemically novel, potent, and selective β1-adrenergic antagonist
- Nebivolol: a third-generation β-blocker that augments vascular nitric oxide release: endothelial β2-adrenergic receptor-mediated nitric oxide production
- Third-generation β-blockers stimulate nitric oxide release from endothelial cells through ATP efflux
- Pharmacological mechanisms of clinically favorable properties of a selective β1-adrenoceptor antagonist, nebivolol (a review)
- Nebivolol: a highly selective β1-adrenergic receptor blocker that causes vasodilation by increasing nitric oxide (a review)
- RP-HPLC and HPTLC methods for the estimation of nebivolol hydrochloride in tablet dosage form
- A validated UV spectrophotometric method for estimation of nebivolol hydrochloride in bulk and pharmaceutical formulation
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