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CAS RN: 182431-12-5 | Product Number: L0298
Lomitapide
Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- N-(2,2,2-Trifluoroethyl)-9-[4-[4-[4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido]piperidin-1-yl]butyl]-9H-fluorene-9-carboxamide
- AEGR-733
- BMS-201038
Product Documents:
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* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
Product Number | L0298 |
Purity / Analysis Method | >98.0%(HPLC)(qNMR) |
Molecular Formula / Molecular Weight | C__3__9H__3__7F__6N__3O__2 = 693.73 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Refrigerated (0-10°C) |
Condition to Avoid | Heat Sensitive |
Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
CAS RN | 182431-12-5 |
Reaxys Registry Number | 13754976 |
PubChem Substance ID | 354335361 |
MDL Number | MFCD16620494 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(qNMR) | min. 98.0 % |
NMR | confirm to structure |
Properties (reference)
Melting Point | 142 °C |
GHS
Related Laws:
Transport Information:
H.S.code* | 2933.39-000 |
Application
Lomitapide: A Microsomal Triglyceride Transfer Protein (MTP) Inhibitor
Lomitapide (AEGR-733 or BMS-201038) is a microsomal triglyceride transfer protein (MTP) inhibitor. MTP is a lipid transfer protein that resides in the endoplasmic reticulum of hepatocytes and intestinal epithelial cells, and is required for the assembly and secretion of apolipoprotein B (apo B)-containing lipoproteins by the liver and by the intestine. Lomitapide directly binds and inhibits MTP, thereby preventing the assembly of apolipoprotein B-containing lipoproteins in hepatocytes and intestinal epithelial cells. This inhibits the synthesis chylomicros of and very low-density lipoprotein (VLDL). The inhibition of the synthesis of VLDL leads to reduced levels of low-density lipoprotein cholesterol (LDC-C) in plasma. In addition, lomitapide mesylate [CAS: 202914-84-9] is used for clinical. (The product is for research purpose only.)
References
- Influence of triacylglycerol biosynthesis rate on the assembly of apoB-100-containing lipoproteins in Hep G2 cells.
- An MTP Inhibitor That Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits
- Lomitapide, a microsomal triglyceride transfer protein inhibitor for the treatment of hypercholesterolemia (a review)
- Microsomal transfer protein inhibition in humans (a review)
PubMed Literature
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