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CAS RN: 137-58-6 | Product Number: L0156
Lidocaine
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Purity: >99.0%(T)(HPLC)
Synonyms:
- 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 25G |
₩87,000
|
14 | ≥80 |
| 100G |
₩240,500
|
14 | 26 |
| 500G |
₩782,600
|
15 | ≥80 |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | L0156 |
| Purity / Analysis Method | >99.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__2__2N__2O = 234.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 137-58-6 |
| Reaxys Registry Number | 2215784 |
| PubChem Substance ID | 87572107 |
| SDBS (AIST Spectral DB) | 27423 |
| Merck Index (14) | 5482 |
| MDL Number | MFCD00026733 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Melting point | 66.0 to 70.0 °C |
| Solubility in Methanol | almost transparency |
Properties (reference)
| Melting Point | 69 °C |
| Boiling Point | 182 °C/4 mmHg |
| Solubility in water | Insoluble |
| Degree of solubility in water | 410 mg/l 30 °C |
| Solubility (soluble in) | Alcohol, Benzene, Ether, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H362 : May cause harm to breast-fed children. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P272 : Contaminated work clothing should not be allowed out of the workplace. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | AN7525000 |
Transport Information:
| H.S.code* | 2924.29-000 |
Application
Lidocaine: A Voltage Gated Sodium Channel Blocker
Lidocaine is widely used for regional anesthesia and postoperative pain relief, and these effects involve the blockade of voltage-dependent sodium channels which play a key role in the pathogenesis of neuropathic pain. Thus, lidocaine stabilizes the neuronal cell membrane by inhibiting the movement of sodium ions into a nerve cell. Lignocaine is also a class IB antiarrhythmic agent as a sodium channel blocker. Lidocaine is metabolized rapidly by CYP1A2 and CYP3A4 in liver to main active metabolites, monoethylglycine xylidide (MEGX) [N1171] and glycinexylidide (GX) [G0579]. (The product is for research purpose only.)
References
- Lidocaine block of cardiac sodium channels
- Molecular determinants of state-dependent block of Na+ channels by local anesthetics
- The role of sodium channels in chronic inflammatory and neuropathic pain (a review)
- High-performance liquid chromatography-tandem electrospray mass spectrometry for the determination of lidocaine and its metabolites in human plasma and urine
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