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CAS RN: 123663-49-0 | Product Number: I0945
Iguratimod
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N-(3-Formamido-4-oxo-6-phenoxy-4H-chromen-7-yl)methanesulfonamide
- N-[7-(Methanesulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl]formamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 25MG |
₩40,700
|
15 | 4 |
| 250MG |
₩242,400
|
17 | 31 |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | I0945 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__4N__2O__6S = 374.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 123663-49-0 |
| Reaxys Registry Number | 8640145 |
| PubChem Substance ID | 253660421 |
| MDL Number | MFCD00882374 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 238.0 to 242.0 °C |
Properties (reference)
| Melting Point | 240 °C |
| Solubility in water | Insoluble |
| Solubility (insoluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
Transport Information:
| H.S.code* | 2935.90-000 |
Application
Iguratimod (T-614): An Agent with Anti-Inflammatory and Immunomodulatory Activities
Iguratimod (T-614) is an agent with anti-inflammatory and immunomodulatory activities. Iguratimod inhibits the production of immune globulin and inflammatory cytokines such as TNF-α, IL-1β and IL-6 in vitro. Even though the mechanism of action of iguratimod is still not fully understood, the suppression of nuclear factor kappa B (NF-κB) activation has been indicated. Iguratimod is used as a disease modifying anti-rheumatic drug (DMARD). (The product is for research purpose only.)
References
- Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one. 1st Communication: antiinflammatory, analgesic and other related properties
- K. Tanaka, T. Shimotori, S. Makino, Y. Aikawa, T. Inaba, C. Yoshida, S. Takano, Arzneim.-Forsch. 1992, 42, 935.
- Synthesis and antiinflammatory activity of 7-methanesulfonylamino-6-phenoxychromones. Antiarthritic effect of the 3-formylamino compound (T-614) in chronic inflammatory disease models
- An anti-rheumatic agent T-614 inhibits NF-κB activation in LPS- and TNF-α-stimulated THP-1 cells without interfering with IκBα degradation
- Inhibitory effects of an anti-rheumatic agent T-614 on immunoglobulin production by cultured B cells and rheumatoid synovial tissues engrafted into SCID mice
- Determination of iguratimod in rat plasma by high performance liquid chromatography: method and application
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