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CAS RN: 149647-78-9 | Product Number: H1388
N-Hydroxy-N'-phenyloctanediamide
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Purity: >98.0%(HPLC)(N)
Synonyms:
- SAHA
- Suberoylanilidehydroxamic Acid
- Vorinostat
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
₩272,000
|
≥80 | 29 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | H1388 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__4H__2__0N__2O__3 = 264.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 149647-78-9 |
| Reaxys Registry Number | 7213017 |
| PubChem Substance ID | 160871381 |
| Merck Index (14) | 10034 |
| MDL Number | MFCD00945317 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
Properties (reference)
| Melting Point | 155 °C |
| Degree of solubility in water | 1,167 mg/l 25 °C |
| Solubility (slightly sol. in) | Ethanol, Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | RG8835000 |
Transport Information:
| H.S.code* | 2928.00-000 |
Application
Hypoxia inducible factor (HIF) research / Hypoxia inducible factor (HIF) inhibitor
Reference
- Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth.
Application
Reticulophagy research / ER (endoplasmic reticulum) phagy
Reference
- Suberoylanilide hydroxamic acid upregulates reticulophagy receptor expression and promotes cell death in hepatocellular carcinoma cells
Application
Adeno-associated virus vector transduction enhancer
N-Hydroxy-N'-phenyloctanediamide (Vorinostat) increases transduction by adeno-associated virus (AAV) vectors.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
Application
HDAC Inhibitor
Suberoylanilidehydroxamic acid (SAHA) is a histone deacetylase (HDAC) inhibitor1,2) and inhibits both classes I and II enzymes by binding to the pocket of the catalytic site.3) The compound has been demonstrated to inhibit the proliferation of a wide variety of transformed cells in vitro.1)
References
- 1) Cancer biology: mechanism of antitumor action of vorinostat (suberoylanilide hydroxamic acid), a novel histone deacetylase inhibitor
- 2) A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
- 3) Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
PubMed Literature
Articles/Brochures
TCIMAIL
[TCIMAIL No.157] HDAC Inhibitor[Research Articles] HDAC2 may be a New Target for Schizophrenia Treatment
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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