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CAS RN: 95975-55-6 | Product Number: G0629
Guggulsterone [mixture of (E)- and (Z)- isomers]
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Purity: >98.0%(HPLC)
Synonyms:
- Pregna-4,17(20)-diene-3,16-dione [mixture of (E)- and (Z)- isomers]
- Pregna-4,17-diene-3,16-dione [mixture of (E)- and (Z)- isomers]
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 250MG |
₩580,900
|
11 | 20 |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | G0629 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__8O__2 = 312.45 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 95975-55-6 |
| Reaxys Registry Number | 5294518 |
| MDL Number | MFCD01310757 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of isomers) |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
| RTECS# | TU3670500 |
Transport Information:
| H.S.code* | 2914.29-000 |
Application
Guggulsterone: A Bioactive Plant Sterol
Guggulsterone is a plant sterol and bioactive compound found in the gum guggul of Commiphora wightii, which has been used as a traditional herbal medicine. Guggulsterone has been reported to bind to the farnesoid X receptor (FXR), a member of the nuclear hormone receptor superfamily, and decrease the expression of bile acid-activated genes.1) Guggulsterone has been found to potently inhibit the activation of nuclear factor-κB (NF-κB), a critical regulator of inflammatory responses.1) Furthermore, guggulsterone modulates the expression of proteins with anti-apoptotic (IAP1, XIA, P, Bfl-1/A1, Bcl-2, cFLIP, survivin), cell survival, cell proliferation (cyclin D1, c-Myc), angiogenic, and metastatic (MMP-9, COX-2, VEGF) activities in tumor cells.1-5) (The product is for research purpose only.)
References
- 1) Guggulsterone inhibits NF-κB and IκBα kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis
- 2)Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits (a review)
- 3) Guggulsterone and Its Role in Chronic Diseases (a review)
- 4) Guggulsterone for Chemoprevention of Cancer (a review)
- 5) Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials
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