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CAS RN: 64048-12-0 | Product Number: G0626
GANT 58
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Purity: >93.0%(qNMR)
Synonyms:
- 2,3,4,5-Tetra(4-pyridyl)thiophene
- 4-[2,4,5-Tri(4-pyridinyl)-3-thienyl]pyridine
- 4,4',4'',4'''-(Thiophene-2,3,4,5-tetrayl)tetrapyridine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 10MG |
₩336,700
|
18 | 20 |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | G0626 |
| Purity / Analysis Method | >93.0%(qNMR) |
| Molecular Formula / Molecular Weight | C__2__4H__1__6N__4S = 392.48 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 64048-12-0 |
| Reaxys Registry Number | 47834 |
| MDL Number | MFCD01103196 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 93.0 % |
| Melting point | 249.0 to 253.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 250 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
GANT 58: A Hedgehog/GLI (Hh/GLI) Signaling Pathway Inhibitor (Antagonist)
Hedgehog (Hh) signaling, which plays a critical role in cell proliferation and survival, has also been implicated in cancer initiation and progression. Glioma-associated oncogene (GLI) is an important nuclear transcription factor in Hh signaling and tumorigenesis. GANT 58 inhibits the Hedgehog/GLI (Hh/GLI) signaling pathway and induces apoptosis in cancer cell lines. (The product is for research purpose only.)
References
- Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
- Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells
- Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened (a review)
- Current trends in Hedgehog signaling pathway inhibition by small molecules (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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