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CAS RN: 162359-56-0 | Product Number: F1018
Fingolimod Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Amino-2-[2-(4-n-octylphenyl)ethyl]propane-1,3-diol Hydrochloride
- FTY 720
- 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
₩216,500
|
21 | 0 | Contact Us | |
| 1G |
₩732,600
|
17 | 0 | It can be shipped in about 1 week after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | F1018 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__3__3NO__2·HCl = 343.94 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 162359-56-0 |
| Related CAS RN | 162359-55-9 |
| Reaxys Registry Number | 7837310 |
| PubChem Substance ID | 253660828 |
| Merck Index (14) | 4083 |
| MDL Number | MFCD00939512 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 110 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | TY3130000 |
Transport Information:
| H.S.code* | 2922.19-000 |
Application
Fingolimod hydrochloride (FTY720): An Immunomodulatory Agent Working as a Sphingosine 1-Phosphate Receptor Agonist
Fingolimod was first synthesized in 1992 by chemical modification of an immunosuppressive natural product, myriocin which is a metabolite of the fungus. Fingolimod hydrochloride (FTY720) is an orally active immunomodulatory agent, and inhibits lymphocyte emigration from lymphoid organs. Recent data show that FTY720 is a prodrug, and phosphorylated FTY720 is an agonist at sphingosine 1-phosphate (S1P) receptors. FTY720 is commonly used for the treatment of multiple sclerosis, an inflammatory disorder of the central nervous system. (The product is for research purpose only.)
References
- FTY720 Story. Its Discovery and the Following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology (a review)
- Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
- The immune modulator FTY720 targets sphingosine 1-phosphate receptors
- FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function (a review)
- Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis (a review)
- FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
PubMed Literature
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TCIMAIL
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