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CAS RN: 138977-28-3 | Product Number: C3923
Capsazepine
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Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- N-(4-Chlorophenethyl)-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carbothioamide
- N-[2-(4-Chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carbothioamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
₩270,100
|
5 | 2 | It can be shipped in about 3-4 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | C3923 |
| Purity / Analysis Method | >98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__9H__2__1ClN__2O__2S = 376.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 138977-28-3 |
| Reaxys Registry Number | 7047754 |
| MDL Number | MFCD00153778 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 157.0 to 161.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 159 °C |
| Solubility (soluble in) | Ethanol |
GHS
Related Laws:
| RTECS# | CX7075000 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Capsazepine: A Competitive Antagonist of TRPV1
Capsazepine is a synthetic analog of capsaicin [M1149] [M0900] that can act as a competitive antagonist of transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel that can be activated by a variety of exogenous and endogenous physical and chemical stimuli.1-3) Recently, capsazepine has been reported to exhibit pleiotropic anticancer effects as an apoptosis inducer against numerous tumor cell lines.4) (The product is for research purpose only.)
References
- 1) Capsazepine: a competitive antagonist of the sensory neuron excitant capsaicin
- 2) Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurons in culture
- 3) The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain
- 4) Pleiotropic pharmacological actions of capsazepine, a synthetic analogue of capsaicin, against various cancers and inflammatory diseases (a review)
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