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CAS RN: 120202-66-6 | Product Number: C2556
(S)-(+)-Clopidogrel Sulfate
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Purity: >98.0%(HPLC)(N)
Synonyms:
- Methyl (S)-(+)-2-(2-Chlorophenyl)-2-[6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]acetate Sulfate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
₩259,000
|
≥40 | 7 | It can be shipped in about 3 months after ordering | |
| 5G |
₩889,900
|
17 | ≥100 | It can be shipped in about 3 months after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | C2556 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__6H__1__6ClNO__2S·H__2SO__4 = 419.89 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 120202-66-6 |
| Related CAS RN | 113665-84-2 |
| Reaxys Registry Number | 9967887 |
| PubChem Substance ID | 125308051 |
| MDL Number | MFCD00876395 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Optical Isomer | max. 0.5 % |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | +54.0 to +58.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | 56° (C=1,MeOH) |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
(S)-(+)-Clopidogrel Sulfate: An Antiplatelet Agent Acting as a P2Y12 ADP Receptor Antagonist
(S)-(+)-Clopidogrel sulfate is a thienopyridine class inhibitor of platelet activation and aggregation through the binding the P2Y12 class of adenosine diphosphate (ADP) receptors on platelets. (S)-(+)-Clopidogrel is must be metabolized by CYP450-2C19 enzymes in liver to produce the thiol active metabolite antagonizes binding irreversibly to the P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.1-4) On the other hand, the (R)-enantiomer has no antithrombotic activity.5) (S)-(+)-Clopidogrel has been often used in combination with acetylsalicylic acid (aspirin) [A2262] to the treatment of ischemic vascular disease.4) For your reference, [T2770] is a synthetic intermediate of (S)-(+)-clopidogrel. (The product is for research purpose only.)
References
- 1) P2Y12, a New Platelet ADP Receptor, Target of Clopidogrel
- 2) Identification of the platelet ADP receptor targeted by antithrombotic drugs
- 3) Clopidogrel: a review of its use in the prevention of thrombosis
- 4) Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update
- 5) Developments in the synthesis of the antiplatelet and antithrombotic drug (S)-clopidogrel (a review)
PubMed Literature
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