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CAS RN: 714971-09-2 | Product Number: B5520
BMS-599626
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Purity: >98.0%(HPLC)
Synonyms:
- AC 480
- (S)-Morpholin-3-ylmethyl [4-[[1-(3-Fluorobenzyl)-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
₩246,100
|
4 | 1 | Contact Us | |
| 50MG |
₩854,700
|
17 | 1 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | B5520 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__2__7FN__8O__3 = 530.56 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 714971-09-2 |
| Reaxys Registry Number | 18544666 |
| PubChem Substance ID | 468590608 |
| MDL Number | MFCD10565678 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 20.00 to 22.00 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
BMS-599626: A Highly Selective Inhibitor of HER1 and HER2
BMS-599626 (or AC480) is a highly selective inhibitor of human epidermal growth factor receptors (HER) kinase family which plays essential roles in regulating cell proliferation, survival, differentiation and migration. BMS-599626 modulates signaling and growth of tumor cells that depend on HER1 and/or HER2. Reportedly, BMS-599626 inhibits HER1 and HER2 with IC50 of 20 and 30 nmol/L, respectively. (The product is for research purpose only.)
References
- Preclinical Antitumor Activity of BMS-599626, a pan-HER Kinase Inhibitor That Inhibits HER1/HER2 Homodimer and Heterodimer Signaling
- HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924
- AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo
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