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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 5534-09-8 | Product Number: B4464
Beclometasone Dipropionate
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
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| 1G |
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22 | ≥100 | Contact Us | |
| 5G |
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20 | ≥40 | Contact Us |
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* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | B4464 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__3__7ClO__7 = 521.05 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 5534-09-8 |
| Reaxys Registry Number | 3638107 |
| PubChem Substance ID | 253662548 |
| Merck Index (14) | 1019 |
| MDL Number | MFCD00135613 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +88.0 to +94.0 deg(C=1, Dioxane) |
Properties (reference)
| Melting Point | 208 °C(dec.) |
| Specific Rotation | 90° (C=1,Dioxane) |
| Maximum Absorption Wavelength | 238(EtOH) nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | TU3805000 |
Transport Information:
| H.S.code* | 2937.29-000 |
Application
Beclomethasone Dipropionate: A Prodrug with Weak Glucocorticoid Receptor Binding Affinity
Beclomethasone dipropionate (BDP), a synthetic ant-inflammatory glucocorticoid and corticosteroid, is a prodrug with weak glucocorticoid receptor binding affinity. BDP is hydrolyzed with esterase enzymes to an active metabolite beclomethasone 17-monopropionate and minor inactive metabolites, beclomethasone 21-monopropionate and beclomethasone. BDP is freely soluble in acetone and ethanol, soluble in chloroform, and very slightly soluble in water. BDP is used for treatment of asthma and rhinitis. (The product is for research purpose only.)
References
- Beclomethasone dipropionate. A reappraisal of its pharmacodynamic properties and therapeutic efficacy after a decade of use in asthma and rhinitis (a review)
- Review of the toxicology of beclomethasone dipropionate
- Beclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in man
- Sensitive liquid chromatographic/tandem mass spectrometric method for the determination of beclomethasone dipropionate and its metabolites in equine plasma and urine
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