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CAS RN: 181183-52-8 | Product Number: A3111
Almotriptan Malate
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Purity: >98.0%(HPLC)
Synonyms:
- 3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indole Malate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 25MG |
₩153,600
|
1 | Contact Us |
| 100MG |
₩366,300
|
28 | 2 |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | A3111 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__5N__3O__2S·C__4H__6O__5 = 469.55 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 181183-52-8 |
| Related CAS RN | 154323-57-6 |
| Reaxys Registry Number | 15435698 |
| PubChem Substance ID | 468590147 |
| Merck Index (14) | 304 |
| MDL Number | MFCD08067740 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 8.50 to 9.50 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 162 °C(dec.) |
| Solubility in water | Soluble |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2935.90-000 |
Application
Almotriptan Malate: A Selective 5-HT1B/1D Receptor Agonist
Almotriptan malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, known as triptan. Almotriptan binds with high affinity to 5-HT1B, 5-HT1D, and 5-HT1F receptors, and has weak affinity for 5-HT1A and 5-HT7 receptors. However, almotriptan has no significant affinity at 5-HT2, 5-HT3, 5-HT4 or 5-HT6. Triptans, including almotriptan, are major advance in the treatment of migraine. The therapeutic activity of triptans in migramine can most likely to be attributed to agonist effects at 5-HT1B/1D receptors on the intracranial blood vessels. (The product is for research purpose only.)
References
- Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine
- Almotriptan, a New Anti‐Migraine Agent: A Review
- Triptans in migraine: A comparative review of pharmacology, pharmacokinetics and efficacy
- A validated reversed phase HPLC method for the determination of process-related impurities in almotriptan malate active pharmaceutical ingredient
- A validated RP HPLC method for estimation of almotriptan malate in pharmaceutical dosage form
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