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CAS RN: 104075-48-1 | Product Number: A2956
Atipamezole Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
₩405,200
|
2 | 4 | Contact Us | |
| 100MG |
₩1,219,200
|
4 | 11 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | A2956 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__6N__2·HCl = 248.75 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 104075-48-1 |
| Related CAS RN | 104054-27-5 |
| Reaxys Registry Number | 8164642 |
| PubChem Substance ID | 354334070 |
| Merck Index (14) | 861 |
| MDL Number | MFCD06407819 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 218.0 to 222.0 °C |
Properties (reference)
| Melting Point | 220 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Ethanol |
| Solubility (insoluble in) | Acetone |
GHS
Related Laws:
| RTECS# | NI6139000 |
Transport Information:
| H.S.code* | 2933.29-000 |
Application
Atipamezole: An α2-Adrenoceptor Antagonist
Atipamezole hydrochloride is a potent and selective α2-adrenoceptor antagonist with an imidazole structure. In animals, it promotes the release of the neurotransmitter noradrenaline in the central as well as in the peripheral nervous systems. The α2/α1 selectivity ratio are considerably higher than those of yohimbine hydrochloride [Y0002]. Unlike many other α2-adrenoceptor antagonists, atipamezole has negligible affinity for 5-HT1A receptors. Atipamezole hydrochloride is used for the reversal of an α2-agonist (e.g. xylazine hydrochloride [X0059]) induced sedation in animals. (The product is for research purpose only.)
References
- Highly selective and specific antagonism of central and peripheral α2-adrenoceptors by atipamezole
- Evaluation of the effects of a specific α2-adrenoceptor antagonist, atipamezole, on α1- and α2-adrenoceptor subtype binding, brain neurochemistry and behavior in comparison with yohimbine
- Actions of α2 adrenoceptor ligands at α2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for α2A adrenoceptors
- Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective α2-adrenoceptor antagonist
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