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CAS RN: 144701-48-4 | Product Number: T2861
Telmisartan
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4'-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic Acid
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
¥8,100
|
7 | 7 | ≥40 | |
| 5G |
¥27,800
|
10 | 6 | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | T2861 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__3__3H__3__0N__4O__2 = 514.63 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 144701-48-4 |
| Reaxys Registry Number | 6624054 |
| PubChem Substance ID | 160870925 |
| Merck Index (14) | 9129 |
| MDL Number | MFCD00918125 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 269 °C |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
| RTECS# | DV2037500 |
Transport Information:
Application
Telmisartan: An Angiotensin II Receptor Type 1 (AT1) Antagonist
Telmisartan is an angiotensin II receptor type 1 (AT1) antagonist. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Angiotensin II, a vasoconstrictor substance, is the principal pressor agent of the renin-angiotensin system. Telmisartan blocks the effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues. Thereby, telmisartan reduces peripheral vascular resistance and blood pressure. There is also an AT2 receptor found in many tissues, but AT2 is not known to be associated with cardiovascular homeostasis. Telmisartan has much greater affinity for the AT1 receptor than for the AT2 receptor. For your reference, our product [D5079] is a key synthetic intermediate of telmisartan. (The product is for research purpose only.)
References
- Identification of Telmisartan as a Unique Angiotensin II Receptor Antagonist With Selective PPARγ-Modulating Activity
- Angiotensin Type 1 Receptor Blockers Induce Peroxisome Proliferator-Activated Receptor-γ Activity
- A review on telmisartan: A novel, long-acting angiotensin II-receptor antagonist
- W. Wienen, M. Entzeroth, J. C. A. Van Meel, J. Stangier, U. Busch, T. Ebner, J. Schmid, H. Lehmann, K. Matzek, J. Kempthorne-Rawson, et al., Cardiovasc. Drug Rev. 2000, 18, 127.
PubMed Literature
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