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CAS RN: 104206-65-7 | Product Number: N1054
Nitisinone
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione
- 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
¥9,400
|
14 | 3 | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | N1054 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__0F__3NO__5 = 329.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 104206-65-7 |
| Reaxys Registry Number | 8639943 |
| PubChem Substance ID | 468592462 |
| MDL Number | MFCD01752192 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 138 °C |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Ether, Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | GV0766666 |
Transport Information:
Application
Nitisinone: A Competitive Inhibitor of 4-Hydroxyphenyl-Pyruvate Dioxygenase (HPPD)
Nitisinone (NTBC) is a competitive inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) which is an enzyme upstream of fumarylacetoacetate hydrolase (FAH) in the tyrosine catabolic pathway. By inhibiting HPPD, nitisinone prevents the production and accumulation of the catabolic intermediate metabolites of tyrosine, such as maleylacetoacetate fumarylacetoacetate. In clinical practice, patients with hereditary tyrosinemia type 1 (HT-1) who are deficient in fumarylacetoacetate hydrolase (FAH) required for the metabolism of the catabolic intermediate metabolites, have been reported to produce the toxic metabolites succinylacetone and succinylacetoacetate from these catabolic intermediate metabolites. Therefore, in HT-1 patients, nitisinone would suppresses tissue damage caused by the toxic metabolites. (The product is for research purpose only.)
References
- Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase
- From toxicological problem to therapeutic use: The discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug (a review)
- Comparison of plasma and dry blood spots as samples for the determination of nitisinone (NTBC) by high-performance liquid chromatography-tandem mass spectrometry. Study of the stability of the samples at different temperatures
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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